Learning Team Reflection Essay Example for Free

Learning Team Reflection Essay Owners and managers in the business need to make working capital management decisions such as inventory management, cash-flow management, accounts receivables, and supplier or vendor trade credits to ensure the company has sufficient cash-flows to pay short-term obligations. There are a few different working capital strategies a business can employ. Flexible current asset management involves holding large cash balances and inventory. The restrictive current asset management strategy requires companies to keep current assets low. Finagle a Bagel is a young, growing business that applies the working capital trade-off strategy to manage their working capital (Parrino, Kidwell, Bates, 2012). Married entrepreneurs purchased the business when it was a few years old and had four to five stores (University of Phoenix, 2014). The owners encountered many of the same issues commonly associated with running a young business. They had to learn to deal with customers, vendors, and suppliers; however, the larger issue was discovering how to manage their working capital. Maintaining and continually producing working capital is imperative for any business. Effective working capital management ensures the company has enough money to pay the bills. Managing their current assets, inventory, and liabilities are all part of working capital management (Parrino, Kidwell, Bates, 2012). Finagle a Bagel owners focused on mapping out their future and ensuring the business would grow enough to produce a successful cash flow. A successful cash flow, and keen understanding of their banking relationship, will allow the companies to more comfort when taking on debt or liabilities. The strategies Finagle a Bagel use for managing working capital are no different from the plan many companies utilize. The owners established a good rapport with their bank, vendors, and suppliers (University of Phoenix, 2014) which enables them to create the opportunity for positive interest rates and  trade-offs. The good interest rates assist in the short-term and long-term when they need to acquire a line of credit to pay suppliers or to expand the business. The working capital trade-off strategy requires the manager to balance shortage costs against carrying costs (Parrino, Kidwell, Bates, 2012). The business must be flexible. To allow for more time to pay another business back, trade credit is a strategy businesses extend to one another. Businesses work out a type of credit line to provide the other business with a suitable amount of time to pay their bill (Parrino, Kidwell, Bates, 2012). Credit lines are ideal and prevent banks from getting involved. Finagle a Bagel uses the strategy of trade credit regularly. Improper working capital management may jeopardize a company to default or bankruptcy. Upon reviewing the working capital management video, it is inevitable that the owners and managers in a business should monitor cash inflows and outflows periodically by computing financial ratios such as efficiency ratios – inventory turnover, and account receivable turnover and working capital ratio to ensure that the company has adequate cash-flows all the time. References Parrino, R., Kidwell, D. S, Bates, T. W. (2012). Fundamentals of Corporate Finance (2nd ed). Hoboken, NJ: Wiley. University of Phoenix. (2014). Week 3 Electronic Reserve Videos. Retrieved from University of Phoenix, FIN/571 – Foundations of Finance course website.

Women in a Global Economy :: Globalization Economics Essays

Women in a Global Economy The Globalization of the market and corporations have created problems for women everywhere. Because of the search for a higher profit, corporations in the United States move their factories to â€Å"developing† countries. There, they can force the workers to work longer than an eight hour day, and the wages they pay to their employees are considerably less than the minimum wage in the U.S.. When the women in these factories make an effort to fight back by protesting or striking for better pay, or better working conditions, the corporations simply move out. There are many other nations who can work just as hard without all the complaints. So, because these women ask to be treated decently, they are denied a job. This practice has also created problems for women factory workers in the U.S. because the factories here are all being shut down. I knew one woman who lost her job at Motorola because they moved their testing ground to Mexico. The variety of middle class jobs has decre ased in the U.S., creating poorer poor and wealthier rich, who get their money directly or indirectly through the exploitations of poorer countries. The most interesting and best summarizing paragraph of the reading was about The Myth of Progress. (pg. 267) It states that progress is equated with economic growth and ignores â€Å"intellectual, social, moral and spiritual dimensions†, and that this definition persuades people to value themselves according to the materials they are able to obtain. This can create a world of problems. By stressing money and material it is easy for some to forget how it is obtained, both in a methodical, and a humanistic sense. By this I am referring specifically to the people of the three classes in the U.S.. Poor people instead of concentrating on education or buying assets or spiritually connecting and becoming a leader, tend to trade their labor for some money, then use all of it to buy â€Å"stuff†. They’ll buy clothes, or DVDs, or trinkets, and they feel good about these purchases because they got a good deal, and it increases their material value. None of them will think about where or how it was assembled, because they are distanced from it, and are content with their new acquisition. The middle class trade stressful working days for a little more money, with which they use to buy liabilities like cars or boats, again not thinking about the how they came to be.

Synthesis of Certain Derivatives of Schiffbases

Microbiological Studies A definitive diagnosis of tuberculosis can only be made my culturing Mycobacterium tuberculosis organisms from a specimen taken from the patient (Most often sputum, but may also include pus, cerebero spinal fluid (CSF)), biopsied tissue, etc. Sputum smears and cultures should be done for acid-fast bacilli. The preferred method for the identification is fluorescence microscopy which is more sensitive than conventional Ziehl- Neelson staining denoted by Steingart et al. , 2006 6. If sputum is not produced, specimens can be obtained by gastric washings, an laryngeal swab, bronchoscopy with broncho alveolar lavage or fine needle aspiration of a collection. A comparative study found that inducing three sputum samples is more sensitive than three gastric washings. Many types of culture media are available. Traditionally Lowenstein –Jensen (LJ), Kirchner or Middle Brook media (7H9, 7H10, 7H11 and 7H12) are used for cultivating of Mycobacterial species. A culture of the acid-fast bacilli distinguishes the various forms of Mycobacteria. New automated systems that are faster include BACTEC 460 TB, BACTEC 9000 and the Mycobacterial growth Indicator tube (MGIT). The microscopic observation drug susceptibility assay (MODS) culture may be faster and more accurate method. Drugs Used In Tuberculosis in the current scenario Active tuberculosis will kill about two of every three people affected if left untreated. Treated tuberculosis if taken up early has a mortality rate of less than 5%. The standard short course treatment for tuberculosis comprises of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol for two months, then Isoniazid and Rifampicin alone for a further four months. For latent tuberculosis, the standard treatment is six to nine months of Isoniazid alone. Drug regimens are abbreviated in a standardized manner. a). Streptomycin is STM or S b) Isoniazid is INH or H c) Rifampicin is RMP or R d) Ethambutol is EMB or E e) Pyrazinamide is PZA or Z. a)According to WHO norms, there are six classes of second line drugs that are used for the treatment of tuberculosis. A drug may be classified as second line instead of first line for one of two possible reasons; it may be less effective than the first line drugs or it may produce toxic side –effects. They are classified based on their chemical nucleus: Aminoglycosides – Amikacin and Kanamycin b)Polypeptides – Capreomycin c)Fluoroquinolones – Ciprofloxacin d)Thioamides – Ethionamide, Prothionamide and Cycloserine. e)Para-amino Salicylic acid. Tuberculosis has been treated by combination therapy over fifty years. Single drug treatment is ineffective and regimens that use only single drugs result in the rapid development of resistance and thus treatment results in failure. The rationale for using multiple drugs to treat tuberculosis is based on simple probability. The frequency of spontaneous mutations that confer resistance to an individual drug is well known: 1 in 10 7 for Ethambutol (EMB); 1 in 108 for streptomycin (STM) and Isoniazid (INH); 1 in 10 10 for Rifampicin (RMP). A patient with extensive pulmonary tuberculosis has approximately 10 12 bacteria in his body and therefore will probably be harbouring approximately 10 5 Ethambutol resistant bacteria, 10 4 Streptomycin resistant bacteria, 104 Isoniazid resistant bacteria and 102 Rifampicin resistant bacteria respectively. DOTS stands for ‘Directly Observed Therapy, Short – course’ and is a major plank in the WHO global tuberculosis eradication programme. The WHO advises that all tuberculosis patients should have atleast the first two months of their drug therapy should be observed with the aid of observer within that society. DOTS is used with intermittent dosing – Thrice weekly (Rifampicin, Isoniazid, Ethambutol and Pyrazinamide) or twice weekly. The relative incidence of major adverse effects has been carefully described . a)Isoniazid – Hepatitis, Neuropathy – 0. 49%. )Rifampicin – Skin rash, Thrombocytopenia and Hepatitis – 0. 43 % c)Pyrazinamide – Skin rash and Hepatitis – 1. 48 % d)Streptomycin – Vertigo – 0. 43 % Drug Resistant Tuberculosis (MDR and XDR – TB) Multi Drug Resistant Tuberculosis (MDR-TB) is defined as tuberculosis that is resistant at least to Isoniazid and Rifampicin isolates. In the year 200 6 â€Å"Extensively- Drug Resistant Tuberculosis† (XDR-TB) has emerged and defined as multi drug resistant tuberculosis that is resistant to quinolones and also to any one of kanamycin, capreomycin or amikacin. A 1997 survey of 35 countries found that 2% of the tuberculosis populations are infected by drug – resistant tuberculosis. The highest rates were in USSR, The Baltic states, Argentina, India and China. In 2006, MDR –TB in New York city has been increased to 20-30%. Annual risk of mortality rates increases by 10-15%. There is currently an epidemic of XDR-TB in South Africa. The outbreak was first reported as a cluster of 53 patients in a rural hospital in Kwazulu –Natal of whom 52 died . The treatment and prognosis of MDR-TB are much more akin to that of cancer than to that for infection. In these aspects, molecular manipulation is a productive source of new drugs. This research work pertains to the modification of Schiff bases on isoniazid to explore the new drugs with a desire to obtain highly potent, more specific and less toxic drugs. In the foregoing literature retrieval, it had been observed that the drug design can be performed by molecular manipulation and resulting in new productive drugs. The biological study of natural products with medicinally useful property and some of the chemical structure and its analogs had furnished to lead compounds, and its variation in the biological behavior. The pre-existing tuberculosis had made a challenging effect of medicinal chemists resulting in the extreme drug resistance. The performance of molecular manipulation still existed in a major line approach for the discovery of new drug analogues. To synthesize a derivative, an intermediate step has to be performed and to proceed for the further molecular manipulation. Combination of two or more active moieties in to one is a common procedure of manipulation and this can be possibly result in augmenting the activity, removal of untoward side effects and particularly to prevent development of resistance by the infectious microorganisms. Abundant literature support were available with regard to the study of Schiff bases as potent antibacterial, antifungal, antihypertensive, antiviral and anticancer perspectives. Schiff bases were the intermediate for the synthesis of azetidine -2 & 4- ones, thiazolidine -2 & 4- ones, triazoles & tetrazoles. It was interesting to observe that some analogues of Schiff bases were combined with other moieties like phenothiazines,hydrazines and some hydrazide derivatives of carboxylic acid resulting in a better performance in their respective biological activities. Hence, it was our interest to associate the Schiff bases with the primary drug isoniazid. Since Isoniazid is a well known antitubercular drug. As a vast number of reports were been available regarding the antitubercular perspectives of the isoniazid, there is still lacuna existing in the study of Schiff bases in the multi drug and extremely drug resistant M. tb strains. This study will full fill the properties of Schiff bases relevant to the prevailing drug resistant tuberculosis. Biological activities of Schiff bases Schiff bases are of interest and its important moiety which is associated with biological activity. Initially, most of the research program has been conducted to explore the antimicrobial perspectives of Schiff base derivatives. Based on the intermediate Schiff base various molecular manipulation were attempted to investigate and discover an effective antibacterials, antifungals & antiviral agents. In this preview of literature the various activities of Schiff bases pertaining to antibacterial perspectives has been studied. 1. Hearn et. al. , 2003 7 performed enzymatic acylation of the antitubercular isoniazid (INH) by N-acetyl transferases reduces therapeutic effectiveness of the drug. Since it dealt with the major metabolic pathway for INH in human beings, many of these derivatives were prepared and screened against Mycobacterium tuberculosis in the mice. They conclude the structural cogners of metabolites of INH may serve as significant leads in antitubercular drug discovery and in the exploration of the mode of action of INH. 2. Tarek Aboul – fadi et. al. , 2003 8 had synthesized N- alkyl derivative of INH and the Pharmacokinetic studies were been carried out in the bovine and sensitive strains of Mycobacterium tuberculosis. The pharmacokinetic study revealed that the rate and extent absorption of the tested derivatives. They show relative bioavailability of 183. 15 and 443. 25 respectively. 3. Sultana et. al. , 2007 9 studied the synthesis of hydrazones. The study afforded to the hitherto unreported 1-(4-chloro benzylidene) – hydrazinophthalazine, 1- nitrobenzylidene hydrazine phthalazine. , 3-(4-Chlorophenyl) –S-Triazolo (3,4-a) phthalazine. These structures were confirmed by spectroscopic techniques – IR, UV, H-NMR, EIMS, FD & HRMS. Anti hypertensive activity were been evaluated. 4. Koussi and Abdel rahman. , 2006 10 illustrated certain novel Schiff bases of 4- methyl-1,2,4 –triazole -3-mercaptoacetic acid hydrazide were synthesized and their chemical identities were elucidated by elemental analyses. IR, H-NMR,13- C-NMR and mass spectral data. The percentage of the geometrical isomers was elucidated using the 1-H NMR. The synthesized compounds were selected for screening at the tuberculosis antimicrobial acquisition and co-ordination facility against Mycobacterium tuberculosis H37RV strain in which they showed moderate activity at a concentration of 625 mg/mL. . Jiang et. al. , 2003 11 studied the series of chemically modified aryl- aldehyde Schiff bases has been synthesized and tested for their antioxidant activity and radiation protection. It was observed that disulfide –containing aryl –aldehyde schiff base exhibited potent free radical scavenging, antioxidation and radioprotective activities. 6. Pandeya et. al. ,1999 12 synthesized antib acterial, antifungal and anti human immunodeficiency virus activities of Schiff and Mannich bases derived from isatin derivatives and N – (4-(4’ chlorophenyl) thiazolyl thiosemi carbazide. Investigation of antimicrobial activity of compounds was done by agar dilution method. 7. Jayasekar et. al. , 1997 13 synthesized the Schiff bases of mesalazine and studied the anti inflammatory activity. The inhibition shows about 50-60% of the potency of the drug. In the present study, we had investigated certain Schiff base derivatives modified from isoniazid and it has screened for Extreme drug-resistant and Multidrug resistant tuberculosis strain procured from the patients suffering from tuberculosis. Bibilography: 1. Rothschild, B. , Martin, L. , Bercovier, L. G. , Gal, B. G. , Blatt, G. C. , Donoghue, H. , Spigelman, M and Brittain, D. Mycobacterium tuberculosis complex DNA from an extinct bison dated 17,000 years before the present. Clin. Infect. Dis. 30(3) : 305-311 ( 2001). 2. Pearce-Duvet, J. The origin of human pathogens evaluating the role of agriculture and domestic animals in the evolution of human disease. Biol. Rev. Camb. Philos. Soc. 31(3) : 369-382 (2006). 3. Koch, R. Die Aetiolgieder Tuberculosis. Berliner Klinsche Wochenschrift. 19 : 221-230 (1882). 4. Wells, A. Q. The Murine type of tubercle bacillus : Medical Research Council Special Report No. 259. HMSO, London (1946). 5. Mark Spigelman, 2008. Excavated Jericho Bones may help Israeli- Plaestinian – German team to combat tuberculosis. News release, Feb 29, (2008): 1-5. 6. Steingart,K. , Henry,M. , Pasval,G. , Avery,T. O and Lyall, W. H. Fluorescence versus conventional sputum smear microscopy for tuberculosis : a systematic review. Lancet. Infect. Dis. 6 : 570-571 (2006). 7. Michael J Hearn, Michael H Cynamon. Design and synthesis of antituberculars: preparation and evaluation against Mycobacterium tuberculosis of an isoniazid Schiff base. Journal of Anti Microb. Chemotherapy. 53(2):185-191 (2004). . Tarek Aboul-Fadl, Faragany Abdel-Hamid Mohammed, Ehsan Abdel-Saboor Hassan. Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1-alkylisatin and isonicotinic acid hydrazide (INH). ARCHIVES OF PHARMACAL RESEARCH , 26(10):778-784 ( 2003 ). 9. Sultana-N; Sarfaraz-TB; Nelofar-A; Hussain-SA. Potential antibacterial agents: Part VI â₠¬â€œ Synthesis and structure elucidation of schiff bases derived from hydralazine. Pak-J-Sci-Ind-Resch (Pakistan-Journal-of-Scientific-and-Industrial-Research); 50(3); 169-172 (2007). 10. El-Koussi-NA; Abdel-Rahman-HM . Novel 1,2,4-triazole-3-mercaptoacetic acid derivatives as potential antimycobacterial and antimicrobial agents. Bull-Pharm-Sci-Assiut-Univ (Bulletin-of-Pharmaceutical-Sciences); 29(Part 1); 127-136 (2006). 11. Jiang-JJ; Chang-TC; Hsu-WF; Hwang-JM; Hsu-LY. Synthesis and biological activity of sulfur-containing aryl-aldehyde Schiff bases. Chem-Pharm-Bull (Chemical-and-Pharmaceutical-Bulletin); 51(11); 1307-1310 (2003). 12. Pandeya-SN; Sriram-D; Nath-G; De-Clercq-E. Synthesis, antibacterial, antifungal and anti HIV activity of Schiff and Mannich bases of isatin with N-(6-chlorobenzothiazol-2-yl) thiosemicarbazide. Indian-J-Pharm-Sci (Indian-Journal-of-Pharmaceutical-Sciences); 61(6); 358-361 (1999). 13. Jayasekhar-P; Rao-SB; Santhakumari-G. Synthesis and anti-inflammatory activity of Schiff bases of mesalazine. Indian-J-Pharm-Sci (Indian-Journal-of-Pharmaceutical-Sciences); 59(1); 8-12 (1997). 14. Mcomia ; Protective group in Organic chemistry. P-66. 15. Trivedi,P. , Undavia,N. K. ,Dave, A. M. , Bhatt,K. N and Desai ,N. C. Indian Journal of Chem . , Vol 32B(7) : 760-765 ( 1993). 16. Divakar, C. M and Nair, G. R. N. Antiulcer, antibacterial and spermicidal activities of Salanin. Indian Drugs. 38(2): 629-932 (2001).

Essay on Mark Biology and Population Growth Rate - 890 Words

BIOL 1209 Writing Assignment 2 Cover Sheet I certify that the writing in this assignment is my individual work and is my sole intellectual property. It does not contain the ideas, or writing of other individuals/authors. Author: Mark Cooper Jr. Date: 10/24/12 Lab Instructor: Katherine Hovanes Lab Section # 12 Population Ecology Experiment Background: Phosphate is an abiotic factor; therefore, it is a nonliving factor that affects living organism. In this experiment we prose to test the whether variation in environmental phosphate levels affects autotrophic organisms. We ran a lake and Chlamydomonas experiment in order to determine a solution for this question. In our lake experiment we took samples of water†¦show more content†¦Lake Experiment (Ecosystem): Phosphorus Factor Null: Phosphate levels will not influence the abundance of aquatic autotrophic organisms in the lakes. Alternative: Phosphate levels will influence the abundance of aquatic autotrophic organisms in the lakes. Prediction: High levels of phosphate will cause an increase in the abundance of aquatic autotrophic organisms in the lakes. Results: Figure.1: The graphed data represents the growth rate of algae cells (population sizes million cells/mL) in each treatment over 21 day time period. We graphed the population sizes of the control, no-phosphorus, and high-phosphorus treatment. The control group contained 1 ml of Chlamydomonas and 4 ml of phosphate. The no-phosphorus group contained 0.5 ml of Chlamydomonas and 4.5 ml of phosphate . The high-phosphorus treatment contained 3 ml of Chlamydomonas and 2 ml of phosphate. Trend: there is no specific trend represented in the graph. However, No-Phosphorus contained the highest population growth rate with a slope of .19953. The Control and High-Phosphorus treatments had a similar growth rates. However, the Control treatment was higher than the High-Phosphorus treatment. 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